Effects of Acute and Chronic Murine Norovirus Infections on Immune Responses and Recovery from Friend Retrovirus Infection

被引：18

作者：

Ammann, Christoph G. ^{[1
]}

Messer, Ronald J. ^{[1
]}

Varvel, Kimberly ^{[1
]}

DeBuysscher, Blair L. ^{[1
]}

LaCasse, Rachel A. ^{[1
]}

Pinto, Amelia K. ^{[2
]}

Hasenkrug, Kim J. ^{[1
]}

机构：

[1] NIAID, Persistent Viral Dis Lab, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA

[2] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 24期

关键词：

REGULATORY T-CELLS; LEUKEMIA-VIRUS; CD4(+); IDENTIFICATION; COINFECTION; DYSFUNCTION; KINETICS; MOLONEY; VIREMIA; MEMORY;

D O I：

10.1128/JVI.01445-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Murine norovirus (MNV) is a highly infectious but generally nonpathogenic agent that is commonly found in research mouse colonies in both North America and Europe. In the present study, the effects of acute and chronic infections with MNV on immune responses and recovery from concurrent Friend virus (FV) infections were investigated. No significant differences in T-cell or NK-cell responses, FV-neutralizing antibody responses, or long-term recovery from FV infection were observed. We conclude that concurrent MNV infections had no major impacts on FV infections.

引用

页码：13037 / 13041

页数：5

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