Enantioselective catalysis and complexity generation from allenoates

被引：566

作者：

Cowen, Bryan J. ^{[1
]}

Miller, Scott J. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2009年 / 38卷 / 11期

基金：

美国国家科学基金会;

关键词：

ASSISTED PHOSPHINE CATALYSIS; ELECTRON-DEFICIENT OLEFINS; ONE-POT SYNTHESIS; 3+2 CYCLOADDITION; ALLENIC ESTERS; 4+2 ANNULATION; FUNCTIONALIZED CYCLOPENTENES; ETHYL 2,3-BUTADIENOATE; NITROGEN-HETEROCYCLES; ASYMMETRIC-SYNTHESIS;

D O I：

10.1039/b816700c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lewis base catalysis of reactions with allenoates using phosphine and amine nucleophiles has emerged as a key platform for the generation of molecular complexity. Investigations in this area have established a range of suitable coupling partners for allenoates, including electron-deficient olefins, imines, and aldehydes. This tutorial review will describe these methodologies, with a special emphasis on recent work regarding asymmetric reactions using chiral Lewis base catalysts.

引用

收藏

页码：3102 / 3116

页数：15

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