A new, simple, high-affinity glycosidase inhibitor: Analysis of binding through X-ray crystallography, mutagenesis, and kinetic analysis

被引：53

作者：

Williams, SJ

Notenboom, V

Wicki, J

Rose, DR

Withers, SG

机构：

[1] Univ British Columbia, Dept Chem, Prot Engn Networks Ctr Excellence, Vancouver, BC V6T 1Z1, Canada

[2] Univ Toronto, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 17期

关键词：

D O I：

10.1021/ja0002870

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：4229 / 4230

页数：2

共 21 条

[1] 1-aza sugars, apparent transition state analogues of equatorial glycoside formation/cleavage [J].

Bols, M .

ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (01) :1-8

[2] Crystallography & NMR system:: A new software suite for macromolecular structure determination [J].

Brunger, AT ;

Adams, PD ;

Clore, GM ;

DeLano, WL ;

Gros, P ;

Grosse-Kunstleve, RW ;

Jiang, JS ;

Kuszewski, J ;

Nilges, M ;

Pannu, NS ;

Read, RJ ;

Rice, LM ;

Simonson, T ;

Warren, GL .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1998, 54 :905-921

[3] SYNTHESIS OF A GLUCOSE-DERIVED TETRAZOLE AS A NEW BETA-GLUCOSIDASE INHIBITOR - A NEW SYNTHESIS OF 1-DEOXYNOJIRIMYCIN [J].

ERMERT, P ;

VASELLA, A .

HELVETICA CHIMICA ACTA, 1991, 74 (08) :2043-2053

[4]

HAFELINGER G, 1975, CHEM AMIDINES IMIDAT, V1, P1

[5]

Heightman TD, 1999, ANGEW CHEM INT EDIT, V38, P750, DOI 10.1002/(SICI)1521-3773(19990315)38:6<750::AID-ANIE750>3.0.CO

[6]

2-6

[7] 1-N-iminosugars:: Potent and selective inhibitors of β-glycosidases [J].

Ichikawa, Y ;

Igarashi, Y ;

Ichikawa, M ;

Suhara, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (13) :3007-3018

[8] STRUCTURE OF KIFUNENSINE, A NEW IMMUNOMODULATOR ISOLATED FROM AN ACTINOMYCETE [J].

KAYAKIRI, H ;

TAKASE, S ;

SHIBATA, T ;

OKAMOTO, M ;

TERANO, H ;

HASHIMOTO, M ;

TADA, T ;

KODA, S .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (17) :4015-4016

[9] GLYCOSIDE HYDROLASES - MECHANISTIC INFORMATION FROM STUDIES WITH REVERSIBLE AND IRREVERSIBLE INHIBITORS [J].

LEGLER, G .

ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1990, 48 :319-384

[10]

MEGA T, 1983, J BIOCHEM-TOKYO, V94, P1637

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