Steroid receptors in various glial cell lines - Expression and functional studies

被引:9
作者
Cadepond, F [1 ]
Massaad, C [1 ]
Trousson, A [1 ]
Grenier, J [1 ]
Groyer, G [1 ]
Baulieu, E [1 ]
Schumacher, M [1 ]
机构
[1] INSERM, U488, F-94276 Le Kremlin Bicetre, France
来源
CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS | 2002年 / 973卷
关键词
steroid receptors; glial cells;
D O I
10.1111/j.1749-6632.2002.tb04689.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In glial cell lines from the central (CG4, C6) and peripheral (MSC80, CR3a1, and CR1b4) nervous systems, glucocorticoid receptor (GR) messenger RNA was clearly detected and was consistent with significant GR binding and transcriptional activity. Mineralocorticosteroid receptor mRNA was less abundant, with no corresponding binding and lack of transcriptional activity. Other steroid receptors were not significantly detected.
引用
收藏
页码:484 / 487
页数:4
相关论文
共 5 条
[1]   GLIAL-CELLS EXPRESS BOTH MINERALOCORTICOID AND GLUCOCORTICOID RECEPTORS [J].
BOHN, MC ;
HOWARD, E ;
VIELKIND, U ;
KROZOWSKI, Z .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1991, 40 (1-3) :105-111
[2]   Regulation of gene expression by corticoid hormones in the brain and spinal cord [J].
De Nicola, AF ;
Ferrini, M ;
Gonzalez, SL ;
Deniselle, MCG ;
Grillo, CA ;
Piroli, G ;
Saravia, F ;
de Kloet, ER .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1998, 65 (1-6) :253-272
[3]   Distribution of adrenocorticoid receptors in the rat CNS measured by competitive PCR and cytosolic binding [J].
Marlier, LNJL ;
Patacchioli, FR ;
Porzio, O ;
Chiusaroli, R ;
Borboni, P ;
Lauro, R ;
Angelucci, L .
JOURNAL OF MOLECULAR NEUROSCIENCE, 1997, 9 (01) :1-12
[4]   Properties of overlapping EREs: Synergistic activation of transcription and cooperative binding of ER [J].
Massaad, C ;
Coumoul, X ;
Sabbah, M ;
Garlatti, M ;
Redeuilh, G ;
Barouki, R .
BIOCHEMISTRY, 1998, 37 (17) :6023-6032
[5]   Steroid synthesis and metabolism in the nervous system:: Trophic and protective effects [J].
Schumacher, M ;
Akwa, Y ;
Guennoun, R ;
Robert, F ;
Labombarda, F ;
Désarnaud, F ;
Robel, P ;
De Nicola, AF ;
Baulieu, EE .
JOURNAL OF NEUROCYTOLOGY, 2000, 29 (5-6) :307-326