A first asymmetric diamination of olefins

被引:56
作者
Muñiz, K
Nieger, M
机构
[1] Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany
[2] Univ Bonn, Inst Anorgan Chem, D-53121 Bonn, Germany
关键词
diamines; asymmetric synthesis; imido complexes; osmium; diastereoselectivity;
D O I
10.1055/s-2003-36799
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An asymmetric diarnination of olefins employing stable imidoosmium(VIII) complexes is described for the first time. The reaction is based on the use of chiral acrylic esters and related substrates with enantiopure menthol and 8-phenyl menthol as chiral auxiliaries and gives rise to osmaimidazolidines with good to excellent diastereomeric ratios (LIP to 95:5). Removal of the osmium centre and the chiral auxiliary leads to novel enantiopure 1,2,3-trisubstituted compounds.
引用
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页码:211 / 214
页数:4
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