Breast Cancer, Estrogen Receptor and Ligands

被引：102

作者：

Bai, Zhenlin ^{[1
]}

Gust, Ronald ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Pharm, D-14195 Berlin, Germany

来源：

ARCHIV DER PHARMAZIE | 2009年 / 342卷 / 03期

关键词：

Anti-estrogen action; Breast cancer; Estrogen receptor; Ligand; Estrogen action; PROTEIN-COUPLED RECEPTOR; BASIC SIDE-CHAINS; HORMONE-BINDING GLOBULIN; GROWTH-FACTOR RECEPTOR; TRANSCRIPTIONAL ACTIVATION; MOLECULAR-MECHANISMS; BIOLOGICAL EVALUATION; MEMBRANE-RECEPTOR; PROMOTER-CONTEXT; ER ALPHA;

D O I：

10.1002/ardp.200800174

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review emphasizes the relationship of breast cancer, estrogen receptor and ligands, especially the centrality of the estrogen receptor, which mediates on one hand the hormone-induced gene transcription and on the other hand the anti-estrogen action against breast cancer. The characterization of the estrogen receptor ligand-binding domain co-crystallized with agonists or antagonists provided a molecular basis to gain an insight into the regulation of estrogen receptor and, thereby, to describe the mechanism of the hormone therapy in treating breast cancer.

引用

页码：133 / 149

页数：17

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