High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany

被引：27

作者：

Reinert, RR ^{[1
]}

Lütticken, R ^{[1
]}

Al-Lahham, A ^{[1
]}

机构：

[1] Univ Hosp, Natl Reference Ctr Streptococci, Inst Med Microbiol, D-52057 Aachen, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 07期

关键词：

Emm typing; fluoroquinolone resistance; multilocus sequence typing; resistance; Streptococcus pyogenes;

D O I：

10.1111/j.1469-0691.2004.00890.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC greater than or equal to 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.

引用

页码：659 / 662

页数：5

共 15 条

[1] parC mutation conferring ciprofloxacin resistance in Streptococcus pyogenes BM4513
Alonso, R
Galimand, M
Courvalin, P
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) : 3686 - 3687
[2] [Anonymous], 2002, M100S12 NCCLS
[3] Typing of Streptococcus pyogenes strains isolated from throat infections in the region of Aachen, Germany
Brandt, CM
Spellerberg, B
Honscha, M
Truong, ND
Hoevener, B
Lütticken, R
[J]. INFECTION, 2001, 29 (03) : 163 - 165
[4] Macrolide resistance in Streptococcus pyogenes isolates from throat infections in the region of Aachen, Germany
Brandt, CM
Honscha, M
Truong, ND
Holland, R
Hövener, B
Bryskier, A
Lütticken, R
Reinert, RR
[J]. MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 2001, 7 (02): : 165 - 170
[5] Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone
Enright, MC
Spratt, BG
Kalia, A
Cross, JH
Bessen, DE
[J]. INFECTION AND IMMUNITY, 2001, 69 (04) : 2416 - 2427
[6] The activity of Levofloxacin and comparator agents against clinical isolates of Streptococcus pneumoniae collected worldwide during 1999 and 2000
Jones, ME
Blosser-Middleton, RS
Critchley, IA
Thornsberry, C
Sahm, DF
Yamakita, J
Akasaki, M
Karlowsky, JA
[J]. CHEMOTHERAPY, 2002, 48 (05) : 232 - 237
[7] The role of clonality in the global spread of fluoroquinolone-resistant bacteria
Klugman, KP
[J]. CLINICAL INFECTIOUS DISEASES, 2003, 36 (06) : 783 - 785
[8] Activity of six quinolones against 226 recent clinical isolates of Streptococcus pyogenes with reduced susceptibility to ciprofloxacin
Latorre, C
García-Rey, C
García-Perea, A
Perea, E
Aguilar, L
Cercenado, E
García-de-Lomas, J
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 (02) : 301 - 302
[9] PODBIELSKI A, 1991, MED MICROBIOL IMMUN, V180, P213
[10] Macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes in the pediatric population in Germany during 2000-2001
Reinert, RR
Lütticken, R
Bryskier, A
Al-Lahham, A
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (02) : 489 - 493

← 1 2 →