Homodimerization and heterodimerization of SlP/EDG sphingosine-1-phosphate receptors

被引：46

作者：

Van Brocklyn, JR

Behbahani, B

Lee, NH

机构：

[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

[2] Inst Genomic Res, Dept Funct Genomics, Rockville, MD 20850 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2002年 / 1582卷 / 1-3期

关键词：

sphingolipid; lysophospholipid; G protein-coupled receptor; dimerization;

D O I：

10.1016/S1388-1981(02)00141-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingosine-l-phosphate (SIP) binds to and signals through several members of a group of G protein-coupled receptors (GPCRs) known as the S1P/EDG family. Several of these receptors are coexpressed in various cell types and recent reports have shown that biological effects of S1P often require more than one SIP receptor subtype. Recent evidence indicates that many GPCRs exist as dimers. We show that SIP receptors form both homodimers as well as heterodimers with other members of the S1P subfamily of receptors. We also discuss the role that GPCR dimers play in receptor function and what this may mean for SIP signaling. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：89 / 93

页数：5

相关论文

共 32 条

[1] Involvement of the amino terminus of the B2 receptor in agonist-induced receptor dimerization [J].

AbdAlla, S ;

Zaki, E ;

Lother, H ;

Quitterer, U .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) :26079-26084

[2] Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids [J].

An, SZ ;

Bleu, T ;

Huang, W ;

Hallmark, OG ;

Coughlin, SR ;

Goetzl, EJ .

FEBS LETTERS, 1997, 417 (03) :279-282

[3] Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid [J].

An, SZ ;

Bleu, T ;

Hallmark, OG ;

Goetzl, EJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :7906-7910

[4] Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5 [J].

Ancellin, N ;

Hla, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (27) :18997-19002

[5] Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells [J].

Bai, M ;

Trivedi, S ;

Brown, EM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (36) :23605-23610

[6] Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid [J].

Bandoh, K ;

Aoki, J ;

Hosono, H ;

Kobayashi, S ;

Kobayashi, T ;

Murakami-Murofushi, K ;

Tsujimoto, M ;

Arai, H ;

Inoue, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) :27776-27785

[7] Dimerization of the delta opioid receptor: Implication for a role in receptor internalization [J].

Cvejic, S ;

Devi, LA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (43) :26959-26964

[8] Oligomerization of μ- and δ-opioid receptors -: Generation of novel functional properties [J].

George, SR ;

Fan, T ;

Xie, ZD ;

Tse, R ;

Tam, V ;

Varghese, G ;

O'Dowd, BF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (34) :26128-26135

[9] Lysophospholipid enhancement of human T cell sensitivity to diphtheria toxin by increased expression of heparin-binding epidermal growth factor [J].

Goetzl, EJ ;

Kong, Y ;

Kenney, JS .

PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, 1999, 111 (03) :259-269

[10]

Goetzl EJ, 1999, J IMMUNOL, V162, P2049

← 1 2 3 4 →