Dissecting mitochondrial fusion

被引：63

作者：

Chan, David C. ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

DEVELOPMENTAL CELL | 2006年 / 11卷 / 05期

关键词：

D O I：

10.1016/j.devcel.2006.10.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/OPA1.

引用

页码：592 / 594

页数：3

共 10 条

[1] Mitochondrial fusion and fission in mammals
Chan, David C.
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 : 79 - 99
[2] Disruption of fusion results in mitochondrial heterogeneity and dysfunction
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[3] OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
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[J]. CELL, 2006, 126 (01) : 177 - 189
[4] Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria
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[6] Separate fusion of outer and inner mitochondrial membranes
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[J]. EMBO REPORTS, 2005, 6 (09) : 853 - 859
[7] Mitochondrial fusion intermediates revealed in vitro
Meeusen, S
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[J]. SCIENCE, 2004, 305 (5691) : 1747 - 1752
[8] Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1
Meeusen, Shelly
DeVay, Rachel
Block, Jennifer
Cassidy-Stone, Ann
Wayson, Sarah
McCaffery, J. Michael
Nunnari, Jodi
[J]. CELL, 2006, 127 (02) : 383 - 395
[9] Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
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Valette, A
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Lenaers, G
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) : 7743 - 7746
[10] Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane
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Yaffe, MP
Jensen, RE
[J]. MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (06) : 2342 - 2356

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