Antiinflammatory activity of Polygala japonica extract

被引：17

作者：

Kou, Junping ^{[1
]}

Si, Minda ^{[1
]}

Dai, Guofei ^{[1
]}

Lin, Yuwen ^{[1
]}

Zhu, Danni ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Complex Prescript TCM, Nanjing, Peoples R China

来源：

FITOTERAPIA | 2006年 / 77卷 / 06期

关键词：

Polygala japonica; antiinflammatory activity; histamine; carrageenan; picryl chloride;

D O I：

10.1016/j.fitote.2006.04.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antiinflammatory activity of the aqueous extract of Polygala japonica (AEPJ) was investigated in mice and rats to find the pharmacological basis for its ethnomedical use. The extract. produced a significant inhibition of peritoneal and cutaneous vascular permeability induced by acetic acid and histamine, respectively and ear swelling induced by picryl chloride in mice at the dose of 25.0 mg/kg. Moreover, the extract markedly inhibited footpad edema induced by histamine in rats, and decreased prostaglandin E-2 (PGE(2)) content in carrageenan-induced air-pouch at doses of 12.5 and 6.25 mg/kg respectively. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：411 / 415

页数：5

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