Regio- and stereoselective synthesis of the major metabolite of quercetin, quercetin-3-O-β-D-glucuronide

被引：103

作者：

Bouktaib, M

Atmani, A

Rolando, C

机构：

[1] Univ Sci & Technol Lille, CNRS, UMR 8009, Equipe Polyphenols, F-59655 Villeneuve Dascq, France

[2] Univ Sidi Mohamed Ben Abdellah, Fac Sci D Mehraz, Dept Chim, Fes, Morocco

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 35期

关键词：

quercetin; O-glucoside; O-glucuronide; TEMPO oxidation; chemical synthesis;

D O I：

10.1016/S0040-4039(02)01264-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protected quercetin was first transformed selectively in its 3-O-beta-D-glucoside. Further protection of the remaining phenolic hydroxyl group allows a clean oxidation of the glucoside by TEMPO/NaOCl/NaBr under phase transfer conditions into the corresponding glucuronide which was cleanly deprotected to quercetin-3-O-beta-D-glucuronide. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6263 / 6266

页数：4

共 36 条

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