Blood-brain barrier and energy balance

被引：48

作者：

Banks, William A.

机构：

[1] VAMC St Louis, GRECC, St Louis, MO 63125 USA

[2] St Louis Univ, Sch Med, Dept Internal Med, Div Geriatr, St Louis, MO USA

来源：

OBESITY | 2006年 / 14卷

关键词：

blood-brain barrier; peptide; leptin; insulin; secretions;

D O I：

10.1038/oby.2006.315

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The blood-brain barrier (BBB) plays a critical role in the transduction of signals between the central nervous system and peripheral tissues. It does so through several mechanisms, including the direct transport of peptides and regulatory proteins such as insulin and leptin. Another mechanism that may be important is the secretion by brain endothelial cells of substances that affect feeding, such as proinflammatory cytokines and NO. We have recently shown that the BBB is capable of receiving an input from one side and secreting a substance into the other. Additionally, BBB secretions can be modulated by substances that affect feeding, such as adiponectin and lipopolysaccharide.

引用

收藏

页码：234 / 237

页数：4

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