Oct-4:: Lessons of totipotency from embryonic stem cells

被引：77

作者：

Pesce, M

Anastassiadis, K

Schöler, HR

机构：

[1] European Mol Biol Lab, Gene Express Programme, D-69012 Heidelberg, Germany

[2] Univ Penn, New Bolton Ctr, Sch Vet Med, Ctr Transgenesis & Germ Cell Res, Philadelphia, PA 19104 USA

来源：

CELLS TISSUES ORGANS | 1999年 / 165卷 / 3-4期

关键词：

Oct-4; embryonic stem cell; transcription factor; germ cell;

D O I：

10.1159/000016694

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The Oct-4 transcription factor is expressed in embryonic stem cells and germ cells of the mouse embryo. Cells that are driven into embryonic and extraembryonic somatic differentiation lose Oct-4 expression. Oct-4 is crucial for the maintenance of the totipotency of embryonic cells at early developmental stages as demonstrated recently by homologous recombination. Since during embryogenesis Oct-4 is restricted to germ cells, it is possible that it plays a key role for the germline lineage by preventing differentiation of these cells during gastrulation. Thus, Oct-4 appears to be a key regulator of totipotency during the life cycle of mammals. Copyright (C) 1999 S. Karger AG, Basel.

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页码：144 / 152

页数：9

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