Development of a new ultraporous polymer as support in organic synthesis

被引：40

作者：

Deleuze, H ^{[1
]}

Maillard, B

Mondain-Monval, O

机构：

[1] Univ Bordeaux 1, Chim Organ & Organomet Lab, CNRS, UMR 5802, F-33405 Talence, France

[2] CNRS, Ctr Rech Paul Pascal, UPR 8641, F-33600 Pessac, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(02)00263-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper describes the preparation and post-functionalisation of a new polymeric support based on emulsion-derived foams and called polyHIPEs. The remaining pendant vinylic bonds are easily functionalised by a free radical mechanism. The large pores and channels of this material allow an easy access of the reagent in solution toward the grafted species. PolyHIPE-supported thiol, in the presence of an excess of triethylsilane, showed a good activity and selectivity toward reductive cyclisation of 6-bromohex-1-one and 1-allyloxy-2-bromobenzene. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1877 / 1880

页数：4

共 20 条

[1]

Barby D., 1982, European Patent, Patent No. [0060138, 0,060,138]

[2]

Brown AR, 1998, SYNLETT, P817

[3]

Cameron NR, 1996, ADV POLYM SCI, V126, P163

[4] The preparation and use of polyHIPE-grafted reactants to reduce alkyl halides under free-radical conditions [J].

Chemin, A ;

Mercier, A ;

Deleuze, H ;

Maillard, B ;

Mondain-Monval, O .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (04) :366-370

[5] RADICAL CHAIN REDUCTION OF ALKYL-HALIDES, DIALKYL SULFIDES AND O-ALKYL S-METHYL DITHIOCARBONATES TO ALKANES BY TRIALKYLSILANES [J].

COLE, SJ ;

KIRWAN, JN ;

ROBERTS, BP ;

WILLIS, CR .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (01) :103-112

[6]

DEMORA DJ, 1996, TRIBUTYLTIN CASE STU

[7] EMULSION-DERIVED FOAMS - PREPARATION, PROPERTIES, AND APPLICATION [J].

EVEN, WR ;

GREGORY, DP .

MRS BULLETIN, 1994, 19 (04) :29-33

[8]

Giese B., 1986, RADICALS ORGANIC SYN

[9] PROBLEMS AND POSSIBILITIES OF FREE-RADICAL ADDITION OF THIOLS TO UNSATURATED COMPOUNDS [J].

GRIESBAUM, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1970, 9 (04) :273-+

[10]

Hogde F, 1988, SYNTHESIS SEPARATION

← 1 2 →