Breastfeeding history, pregnancy experience and risk of breast cancer

被引:74
作者
Enger, SM [1 ]
Ross, RK [1 ]
Henderson, B [1 ]
Bernstein, L [1 ]
机构
[1] UNIV SO CALIF,KENNETH NORRIS JR COMPREHENS CANC CTR,DEPT PREVENT MED,SCH MED,LOS ANGELES,CA 90033
关键词
breastfeeding; pregnancy; population-based case-control study; breast neoplasms;
D O I
10.1038/bjc.1997.346
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Epidemiological evidence suggests that breastfeeding protects against breast cancer. Whether an effect of age at first breastfeeding is independent of an effect of age at first birth is unclear. We hypothesized that nausea and vomiting in pregnancy, which are associated with elevated serum oestradiol levels during pregnancy, may increase risk. Cases were 452 parous, premenopausal women, 40 years or younger, diagnosed with breast cancer in Los Angeles County from July 1983 to December 1988. Control subjects were matched to cases on age, race, parity and neighbourhood. Pregnancy and breastfeeding histories were obtained from in-person interviews. Odds of breast cancer among women who breastfed for at least 16 months relative to those among women who did not breastfeed was 0.66 [95% confidence interval (CI) 0.41-1.05]. Number of children breastfed was not associated with risk. Risk was lower in women who first breastfed at older ages. Having ever been treated for nausea or vomiting during pregnancy was associated with an increased risk, especially in women experiencing recent pregnancies (OR = 2.03, 95% CI 1.05-3.92). These results support a protective role of breastfeeding and an adverse role of nausea or vomiting during pregnancy in the development of premenopausal breast cancer, especially in the years immediately following pregnancy.
引用
收藏
页码:118 / 123
页数:6
相关论文
共 34 条
[1]   ABSENCE OF ASSOCIATION BETWEEN REPRODUCTIVE VARIABLES AND THE RISK OF BREAST-CANCER IN YOUNG-WOMEN IN SWEDEN AND NORWAY [J].
ADAMI, HO ;
BERGSTROM, R ;
LUND, E ;
MEIRIK, O .
BRITISH JOURNAL OF CANCER, 1990, 62 (01) :122-126
[2]   THE SHORT-TERM AND LONG-TERM EFFECT OF A PREGNANCY ON BREAST-CANCER RISK - A PROSPECTIVE-STUDY OF 802,457 PAROUS NORWEGIAN WOMEN [J].
ALBREKTSEN, G ;
HEUCH, I ;
KVALE, G .
BRITISH JOURNAL OF CANCER, 1995, 72 (02) :480-484
[3]   PHYSICAL EXERCISE AND REDUCED RISK OF BREAST-CANCER IN YOUNG-WOMEN [J].
BERNSTEIN, L ;
HENDERSON, BE ;
HANISCH, R ;
SULLIVANHALLEY, J ;
ROSS, RK .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (18) :1403-1408
[4]   BREAST-FEEDING AND BREAST-CANCER RISK [J].
BRINTON, LA ;
POTISCHMAN, NA ;
SWANSON, CA ;
SCHOENBERG, JB ;
COATES, RJ ;
GAMMON, MD ;
MALONE, KE ;
STANFORD, JL ;
DALING, JR .
CANCER CAUSES & CONTROL, 1995, 6 (03) :199-208
[5]   SHORT-TERM INCREASE IN RISK OF BREAST-CANCER AFTER FULL TERM PREGNANCY [J].
BRUZZI, P ;
NEGRI, E ;
LAVECCHIA, C ;
DECARLI, A ;
PALLI, D ;
PARAZZINI, F ;
DELTURCO, MR .
BRITISH MEDICAL JOURNAL, 1988, 297 (6656) :1096-1098
[6]   LACTATION AND BREAST-CANCER - EVIDENCE FOR A NEGATIVE ASSOCIATION IN PREMENOPAUSAL WOMEN [J].
BYERS, T ;
GRAHAM, S ;
RZEPKA, T ;
MARSHALL, J .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1985, 121 (05) :664-674
[7]   RISK OF BREAST-CANCER IN RELATION TO THE INTERVAL SINCE LAST FULL-TERM PREGNANCY [J].
CUMMINGS, P ;
STANFORD, JL ;
DALING, JR ;
WEISS, NS ;
MCKNIGHT, B .
BRITISH MEDICAL JOURNAL, 1994, 308 (6945) :1672-1674
[8]   HYPEREMESIS GRAVIDARUM IN RELATION TO ESTRADIOL LEVELS, PREGNANCY OUTCOME, AND OTHER MATERNAL FACTORS - A SEROEPIDEMIOLOGIC STUDY [J].
DEPUE, RH ;
BERNSTEIN, L ;
ROSS, RK ;
JUDD, HL ;
HENDERSON, BE .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1987, 156 (05) :1137-1141
[9]   RISK OF OVULATION DURING LACTATION [J].
GRAY, RH ;
CAMPBELL, OM ;
APELO, R ;
ESLAMI, SS ;
ZACUR, H ;
RAMOS, RM ;
GEHRET, JC ;
LABBOK, MH .
LANCET, 1990, 335 (8680) :25-29
[10]  
HENDERSON BE, 1985, CANCER, V56, P1206, DOI 10.1002/1097-0142(19850901)56:5<1206::AID-CNCR2820560541>3.0.CO