Transcription of the Leishmania major Hsp70-I gene locus does not proceed through the noncoding region

被引：7

作者：

Dresel, A ^{[1
]}

Clos, J ^{[1
]}

机构：

[1] BERNHARD NOCHT INST TROP MED,LEISHMANIASIS UNIT,D-20359 HAMBURG,GERMANY

来源：

EXPERIMENTAL PARASITOLOGY | 1997年 / 86卷 / 03期

关键词：

Leishmania; heat shock; Hsp70; transcription termination; RNA polymerase II;

D O I：

10.1006/expr.1997.4161

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Primary transcripts in kinetoplastid protozoa an generally assumed to he multicistronic, We have analysed the transcription in the gene locus which encodes the 70-kDa heat shock protein by using nuclear nln-on analysis. We find that RNA synthesis in the Hsp70-1 gene locus either is terminated or pauses within the intergenic region approximately 250 nt downstream of the polyadenylation site. We therefore propose a discontinuous mode of transcription in the Hsp70 genes of Leishmania major. (C) 1997 Academic Press.

引用

页码：206 / 212

页数：7

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