Working Memory Deficit in Dyslexia: Behavioral and fMRI Evidence

被引：75

作者：

Beneventi, Harald ^{[1
]}

Tonnessen, Finn Egil ^{[2
]}

Ersland, Lars ^{[3
]}

Hugdahl, Kenneth ^{[1
,4
]}

机构：

[1] Univ Bergen, Dept Biol & Med Psychol, Div Cognit Neurosci, N-5009 Bergen, Norway

[2] Univ Stavanger, Dept Educ, Ctr Reading Res, Stavanger, Norway

[3] Haukeland Hosp, Dept Clin Engn, N-5021 Bergen, Norway

[4] Haukeland Hosp, Div Psychiat, N-5021 Bergen, Norway

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2010年 / 120卷 / 01期

关键词：

dyslexia; fMRI; letters; phonological decoding; prefrontal cortex; working memory; SHORT-TERM-MEMORY; DEVELOPMENTAL DYSLEXIA; PREFRONTAL CORTEX; FUNCTIONAL NEUROANATOMY; BRAIN ACTIVATION; PERFORMANCE; CHILDREN; ORGANIZATION; DYSFUNCTION; REHEARSAL;

D O I：

10.3109/00207450903275129

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dyslexia is a condition characterized by difficulty of reading given adequate intelligence and educational opportunities, primarily associated with a phonological processing deficit. In this study we show that dyslexic children also show a deficit in working memory compared to a control group, measured with fMRI. A working memory n-back task with three load levels was used. Behavioral data showed that the dyslexics had poorer performance compared to the controls. fMRI data showed that the dyslexics had reduced activation in the prefrontal and parietal cortices and the cerebellum compared with the controls. These results imply a working memory deficit in dyslexia.

引用

页码：51 / 59

页数：9

共 44 条

[1]

[Anonymous], 1979, Dyslexia: Theory and research

[2] Dissociation of storage and rehearsal in verbal working memory: Evidence from positron emission tomography [J].

Awh, E ;

Jonides, J ;

Smith, EE ;

Schumacher, EH ;

Koeppe, RA ;

Katz, S .

PSYCHOLOGICAL SCIENCE, 1996, 7 (01) :25-31

[3] The fractionation of working memory [J].

Baddeley, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13468-13472

[4]

Baddeley A.D., 1990, HUMAN MEMORY THEORY

[5]

Baddeley A. D., 1986, WORKING MEMORY

[6] A parametric study of prefrontal cortex involvement in human working memory [J].

Braver, TS ;

Cohen, JD ;

Nystrom, LE ;

Jonides, J ;

Smith, EE ;

Noll, DC .

NEUROIMAGE, 1997, 5 (01) :49-62

[7] Imaging cognition II: An empirical review of 275 PET and fMRI studies [J].

Cabeza, R ;

Nyberg, L .

JOURNAL OF COGNITIVE NEUROSCIENCE, 2000, 12 (01) :1-47

[8] Complexity of prefrontal cortical dysfunction in schizophrenia: More than up or down [J].

Callicott, JH ;

Mattay, VS ;

Verchinski, BA ;

Marenco, S ;

Egan, MF ;

Weinberger, DR .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (12) :2209-2215

[9] ACTIVATION OF PREFRONTAL CORTEX IN CHILDREN DURING A NONSPATIAL WORKING-MEMORY TASK WITH FUNCTIONAL MRI [J].

CASEY, BJ ;

COHEN, JD ;

JEZZARD, P ;

TURNER, R ;

NOLL, DC ;

TRAINOR, RJ ;

GIEDD, J ;

KAYSEN, D ;

HERTZPANNIER, L ;

RAPOPORT, JL .

NEUROIMAGE, 1995, 2 (03) :221-229

[10]

Cohen J D, 1994, Hum Brain Mapp, V1, P293, DOI 10.1002/hbm.460010407

← 1 2 3 4 5 →