New macrobicyclic receptors for amino acids

被引：34

作者：

Jullian, V ^{[1
]}

Shepherd, E ^{[1
]}

Gelbrich, T ^{[1
]}

Hursthouse, MB ^{[1
]}

Kilburn, JD ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

host-guest; receptor; amino acid;

D O I：

10.1016/S0040-4039(00)00488-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new receptors, 9 and 13, have been prepared, utilising a pyridyl aryl ether unit in the rim of the macrobicyclic structure, and the crystal structures for both of these receptors are reported. The presence of the pyridyl unit provides additional hydrogen bonding functionality in comparison to earlier structures of this type, and 9 is an effective receptor for N-acetyl L-asparagine carboxylate in CH2Cl2. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3963 / 3966

页数：4

共 14 条

[1]

Bisson AP, 1998, CHEM-EUR J, V4, P845, DOI 10.1002/(SICI)1521-3765(19980515)4:5<845::AID-CHEM845>3.0.CO

[2]

2-#

[3]

CONNORS KA, 1987, BINDING CONSTANTS ME, P24

[4]

Fessmann T, 1999, ANGEW CHEM INT EDIT, V38, P1993, DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1993::AID-ANIE1993>3.0.CO

[5]

2-H

[6] A synthetic receptor for the Cbz-L-Ala-L-Ala-OH dipeptide sequence [J].

Henley, PD ;

Kilburn, JD .

CHEMICAL COMMUNICATIONS, 1999, (14) :1335-1336

[7]

HENLEY PD, 2000, J CHEM SOC P1

[8]

Job P, 1928, ANN CHIM FRANCE, V9, P113

[9] ANTIPICORNAVIRUS ACTIVITY OF SUBSTITUTED PHENOXYBENZENES AND PHENOXYPYRIDINES [J].

MARKLEY, LD ;

TONG, YC ;

DULWORTH, JK ;

STEWARD, DL ;

GORALSKI, CT ;

JOHNSTON, H ;

WOOD, SG ;

VINOGRADOFF, AP ;

BARGAR, TM .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (03) :427-433

[10] Stabilization of a cis amide bond in a host-guest complex [J].

Pernia, GJ ;

Kilburn, JD ;

Essex, JW ;

MortishireSmith, RJ ;

Rowley, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (42) :10220-10227

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