Cyclic homopentapeptides .1. Analogs of tuberactinomycins and capreomycin with activity against vancomycin-resistant enterococci and Pasteurella

被引：12

作者：

Dirlam, JP

Belton, AM

Birsner, NC

Brooks, RR

Chang, SP

Chandrasekaran, RY

Clancy, J

Cronin, BJ

Dirlam, BP

Finegan, SM

Froshauer, SA

Girard, AE

Hayashi, SF

Howe, RJ

Kane, JC

Kamicker, BJ

Kaufman, SA

Kolosko, NL

LeMay, MA

Linde, RG

Lyssikatos, JP

MacLelland, CP

Magee, TV

Massa, MA

Miller, SA

Minich, ML

Perry, DA

Petitpas, JW

Reese, CP

Seibel, SB

Su, WG

Sweeney, KT

Whipple, DA

Yang, BV

机构：

[1] Central Research Division, Pfizer Inc, Groton, CT 06340, Eastern Point Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(97)00186-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 6a-(3',4'-dichlorophenylamino) analog of viomycin was uncovered by a high-throughput screen against the animal health pathogen Pasteurella haemolytica, and has served as a novel lead structure for our infectious disease programs. We report herein the synthesis and activity of analogs of tuberactinomycins and capreomycin that are active against Pasteurella spp., methicillin-resistant Staphylococcus aureus, and vancomycin-resistant enterococci. (C) 1997 Elsevier Science Ltd.

引用

页码：1139 / 1144

页数：6

共 13 条

[1] SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF SOME 3-[(ALKYLTHIO)METHYL]QUINOXALINE 1-OXIDE DERIVATIVES [J].