Noninvasive assessment of cutaneous wound healing using ultrahigh-resolution optical coherence tomography

被引：80

作者：

Cobb, Michael J.

Chen, Yuchuan

Underwood, Robert A.

Usui, Marcia L.

Olerud, John

Li, Xingde

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Div Dermatol, Seattle, WA 98195 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2006年 / 11卷 / 06期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

optical coherence tomography; wound healing; image segmentation and imaging;

D O I：

10.1117/1.2388152

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Ultrahigh-resolution optical coherence tomography (OCT) was used for noninvasive in vivo evaluation of the wound healing process. Cutaneous wounds were induced by 2.5-mm diameter full-thickness punch biopsies on the dorsal surface of seven mice. OCT imaging was performed to assess the structural characteristics associated with the healing process. The OCT results were compared to corresponding histology. Two automated quantitative analysis routines were implemented to identify the dermal-epidermal junction and segment the OCT images. Hallmarks of cutaneous wound healing such as wound size, epidermal migration, dermal-epidermal junction formation, and differences in wound composition were readily identified on the OCT images. Blister formation was also observed. Preliminary findings suggest OCT is a viable tool to noninvasively monitor wound healing in vivo. (c) 2006 Society of Photo-Optical Instrumentation Engineers.

引用

页数：11

共 63 条

[1]

ADAM L, 1983, MED PROG TECHNOL, V9, P227

[2]

[Anonymous], Z13611993 ANSI LAS I

[3]

State of the art in burn treatment [J].