Reversibly caged glutamate: A photochromic agonist of ionotropic glutamate receptors

被引：126

作者：

Volgraf, Matthew

Gorostiza, Pau

Szobota, Stephanie

Helix, Max R.

Isacoff, Ehud Y. ^{[1
]}

Trauner, Dirk

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA

[4] Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 02期

关键词：

D O I：

10.1021/ja067269o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design, synthesis, and biological evaluation of a photochromic glutamate analogue is described. The molecule functions as a reversibly caged neurotransmitter and can be used to influence neural activity with light.

引用

页码：260 / 261

页数：2

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