A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers

被引：27

作者：

Bullido, Maria J.

Martinez-Garcia, Ana

Artiga, Maria J.

Aldudo, Jesus

Sastre, Isabel

Gil, Pedro

Coria, Francisco

Munoz, David G.

Hachinski, Vladimir

Frank, Ana

Valdivieso, Fernando ^{[1
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Dept Biol Mol, E-28049 Madrid, Spain

[2] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[3] Hosp Clin San Carlos, Serv Geriatria, Madrid 28003, Spain

[4] Univ Toronto, Toronto, ON, Canada

[5] St Michaels Hosp, Toronto, ON M5B 1W8, Canada

[6] Univ Western Ontario, London, ON, Canada

[7] UAM, Serv Neurol, Hosp Univ Laz Paz, Madrid 28034, Spain

来源：

NEUROBIOLOGY OF AGING | 2007年 / 28卷 / 04期

关键词：

Alzheimer's disease; genetic risk factor; TAP; APOE; interaction;

D O I：

10.1016/j.neurobiolaging.2006.02.011

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：519 / 523

页数：5

共 17 条

[1]

[Anonymous], 1997, Neurobiol Aging, V18, pS1

[2]

Bauer D, 2002, CURR TOP MICROBIOL, V269, P85

[3] Alzheimer's disease: one disorder, too many genes? [J].