Aβ levels in serum, CSF and brain, and cognitive deficits in APP plus PSI transgenic mice

被引：23

作者：

Liu, L

Tapiola, T

Herukka, SK

Heikkilä, M

Tanila, H

机构：

[1] Univ Kuopio, Dept Neurosci, FIN-70211 Kuopio, Finland

[2] Univ Kuopio, Dept Neurol, FIN-70211 Kuopio, Finland

[3] Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland

来源：

NEUROREPORT | 2003年 / 14卷 / 01期

关键词：

Alzheimer's disease; amyloid; hippocampus; transgenic mouse;

D O I：

10.1097/00001756-200301200-00030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared beta-amyloid peptide (Abeta) levels in the serum, CSF and brain (hippocampus) and correlated these with spatial learning in APP+PSI transgenic mice. Compared with non-transgenic littermates, male 14-month-old APP + PSI mice were impaired in spatial learning in the water maze. Among the APP + PSI mice, only the hippocampal insoluble Abeta42 level correlated with spatial memory (r = -0.44). The levels of insoluble Abeta40 and Abeta42 were highly correlated (r= -0.92), and also correlated with soluble hippocampal Abeta42 (r = 0.64/0.69), which further correlated with the CSF Abeta42 (r = 0.52). None of these parameters correlated with serum Abeta40 levels. These findings support the role of insoluble Abeta42 in memory dysfunction and suggest a model with several pools (insoluble, extracellular soluble, CSF) of Abeta being in partial equilibrium with each other.

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页码：163 / 166

页数：4

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