Tubeimoside-1 Inhibits Glioblastoma Growth, Migration, and Invasion via Inducing Ubiquitylation of MET

被引：28

作者：

Cao, Jiangjun ^{[1
,2
,3
]}

Zhao, Erhu ^{[2
]}

Zhu, Qingzong ^{[2
]}

Ji, Juanli ^{[2
]}

Wei, Zekun ^{[2
]}

Xu, Bo ^{[3
]}

Cui, Hongjuan ^{[2
]}

机构：

[1] Chongqing Three Gorges Med Coll, Chongqing Engn Res Ctr Antitumor Nat Drugs, Chongqing 404120, Peoples R China

[2] Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China

[3] Southwest Univ, Inst Med, Chongqing 400715, Peoples R China

来源：

CELLS | 2019年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

glioblastoma; tubeimoside-1; MET; APOPTOSIS; METASTASIS; RECEPTOR; CELLS;

D O I：

10.3390/cells8080774

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Tubeimoside-1 (TBMS1) is one of the extracts of rhizoma bolbostemmae, which has remarkable anti-cancer function in the treatment of esophagus and gastric cancer in traditional Chinese medicine. However the mechanisms of its anti-cancer function is remain unclear. In this study, we demonstrate that TBMS1 could inhibit cell growth and metastasis in glioblastoma. MET is a member of the receptor tyrosine kinase family, which amplifies frequently in various human cancers. As an important proto-oncogene, multiple inhibitors have been developed for the therapy of cancers. Here, we found TBMS1 could reduce/decrease the protein level of MET via increasing its Ubiquitination degradation. Therefore, TBMS1 is a promising compound for the treatment of glioblastoma and an inhibitor of MET.

引用

页数：13

共 22 条

[1]

[Anonymous], 1999, ED BOARD CHIN HERB S, V5, P502

[2]

MET Signaling Pathway: A Rational Target for Cancer Therapy [J].