5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO:: synthesis and spin trapping properties

被引：71

作者：

Chalier, F

Tordo, P

机构：

[1] CNRS, UMR 6517, Lab Struct & React Especes Paramagnet, F-13397 Marseille 20, France

[2] Univ Aix Marseille 1, Fac St Jerome, F-13397 Marseille 20, France

[3] Univ Aix Marseille 3, Fac St Jerome, F-13397 Marseille 20, France

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 2002年 / 12期

关键词：

D O I：

10.1039/b206909c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nitrone DIPPMPO (5-diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide) was synthesised, isolated as hygroscopic crystals and its X-ray geometry was determined. The purification of DIPPMPO was easy, compared with that of DEPMPO (5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide) and its solutions in phosphate buffer were EPR silent. DIPPMPO exhibits all the advantages of DEPMPO for the spin-trapping of biological free radicals and thus DIPPMPO is a choice tool in this field.

引用

页码：2110 / 2117

页数：8

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