Neuroscience in the era of functional genomics and systems biology

被引：149

作者：

Geschwind, Daniel H. ^{[1
,2
,3
]}

Konopka, Genevieve ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet & Neurobehav Genet, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

NATURE | 2009年 / 461卷 / 7266期

基金：

美国国家卫生研究院;

关键词：

TRANSLATIONAL PROFILING APPROACH; GENE-COEXPRESSION NETWORK; COMPLEX TRAIT ANALYSIS; ADULT-MOUSE BRAIN; CNS CELL-TYPES; NERVOUS-SYSTEM; PROTEIN EXPRESSION; MOLECULAR CHARACTERIZATION; MICROARRAY ANALYSIS; ALZHEIMERS-DISEASE;

D O I：

10.1038/nature08537

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-generating, research that provides a powerful complement to the more directly hypothesis-driven molecular, cellular and systems neuroscience. Genetic and functional genomic studies have already yielded important insights into neuronal diversity and function, as well as disease. One of the most exciting and challenging frontiers in neuroscience involves harnessing the power of large-scale genetic, genomic and phenotypic data sets, and the development of tools for data integration and mining. Methods for network analysis and systems biology offer the promise of integrating these multiple levels of data, connecting molecular pathways to nervous system function.

引用

页码：908 / 915

页数：8

共 82 条

[1] High throughput protein expression screening in the nervous system - needs and limitations [J].

Anderson, Chris N. G. ;

Grant, Seth G. N. .

JOURNAL OF PHYSIOLOGY-LONDON, 2006, 575 (02) :367-372

[2] Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo [J].

Arlotta, P ;

Molyneaux, BJ ;

Chen, J ;

Inoue, J ;

Kominami, R ;

Macklis, JD .

NEURON, 2005, 45 (02) :207-221

[3] Network biology:: Understanding the cell's functional organization [J].

Barabási, AL ;

Oltvai, ZN .

NATURE REVIEWS GENETICS, 2004, 5 (02) :101-U15

[4]

BILDER RM, 2009, NEUROSCIENCE 0120, DOI DOI 10.1016/J.NEUROSCIENCE.2009.01.027

[5] A high-quality catalog of the Drosophila melanogaster proteome [J].

Brunner, Erich ;

Ahrens, Christian H. ;

Mohanty, Sonali ;

Baetschmann, Hansruedi ;

Loevenich, Sandra ;

Potthast, Frank ;

Deutsch, Eric W. ;

Panse, Christian ;

de Lichtenberg, Ulrik ;

Rinner, Oliver ;

Lee, Hookeun ;

Pedrioli, Patrick G. A. ;

Malmstrom, Johan ;

Koehler, Katja ;

Schrimpf, Sabine ;

Krijgsveld, Jeroen ;

Kregenow, Floyd ;

Heck, Albert J. R. ;

Hafen, Ernst ;

Schlapbach, Ralph ;

Aebersold, Ruedi .

NATURE BIOTECHNOLOGY, 2007, 25 (05) :576-583

[6] Complex brain networks: graph theoretical analysis of structural and functional systems [J].

Bullmore, Edward T. ;

Sporns, Olaf .

NATURE REVIEWS NEUROSCIENCE, 2009, 10 (03) :186-198

[7] A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function [J].

Cahoy, John D. ;

Emery, Ben ;

Kaushal, Amit ;

Foo, Lynette C. ;

Zamanian, Jennifer L. ;

Christopherson, Karen S. ;

Xing, Yi ;

Lubischer, Jane L. ;

Krieg, Paul A. ;

Krupenko, Sergey A. ;

Thompson, Wesley J. ;

Barres, Ben A. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (01) :264-278

[8] THG-1pit moves to nucleus at the onset of cerebellar granule neurons apoptosis [J].

Canterini, Sonia ;

Bosco, Adriana ;

De Matteis, Valentina ;

Mangia, Franco ;

Fiorenza, Maria Teresa .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2009, 40 (02) :249-257

[9]

Chatr-aryamontri A, 2008, METHODS MOL BIOL, V484, P305, DOI 10.1007/978-1-59745-398-1_20

[10] Variations in DNA elucidate molecular networks that cause disease [J].

Chen, Yanqing ;

Zhu, Jun ;

Lum, Pek Yee ;

Yang, Xia ;

Pinto, Shirly ;

MacNeil, Douglas J. ;

Zhang, Chunsheng ;

Lamb, John ;

Edwards, Stephen ;

Sieberts, Solveig K. ;

Leonardson, Amy ;

Castellini, Lawrence W. ;

Wang, Susanna ;

Champy, Marie-France ;

Zhang, Bin ;

Emilsson, Valur ;

Doss, Sudheer ;

Ghazalpour, Anatole ;

Horvath, Steve ;

Drake, Thomas A. ;

Lusis, Aldons J. ;

Schadt, Eric E. .

NATURE, 2008, 452 (7186) :429-435

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