Piracetam as an adjuvant to language therapy for aphasia: A randomized double-blind placebo-controlled pilot study

被引:75
作者
Huber, W
Willmes, K
Poeck, K
VanVleymen, B
Deberdt, W
机构
[1] RHEIN WESTFAL TH AACHEN, NEUROL KLIN, SCH LOGOPED, D-52074 AACHEN, GERMANY
[2] UCB, PHARMACEUT SECT, BRAINE LALLEUD, BELGIUM
来源
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION | 1997年 / 78卷 / 03期
关键词
D O I
10.1016/S0003-9993(97)90028-9
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Objective: To determine whether piracetam 4.8g/day together with intensive language therapy improved language function more than language therapy alone. Design: Double-blind, placebo-controlled parallel group study. Setting: Referral speech and language clinic of a university department of neurology. Patients: Sixty-six inpatients with aphasia present between 4 weeks and 36 months. Interventions: Intensive language therapy for 6 weeks in all patients. Thirty-two patients received piracetam 4.8g daily and 34 patients received placebo. Main Outcome Measure: The Aachen Aphasia Test (AAT), a standardized procedure for evaluating the severity of aphasia, was performed at baseline and after 6 weeks' treatment. Results: In 50 patients evaluated for efficacy, a trend toward improvement in the active group was observed in all subtests of the AAT. This trend was statistically significant for absolute differences in recovery of ''written language'' and ''profile level.'' Conclusion: Piracetam appears to have a positive adjuvant effect on the recovery of aphasia in patients receiving intensive language therapy. (C) 1997 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.
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页码:245 / 250
页数:6
相关论文
共 52 条
[1]  
[Anonymous], 1993, APHASIA TREATMENT WO
[2]   THE PHARMACOTHERAPY OF APHASIA - HISTORICAL-PERSPECTIVE AND DIRECTIONS FOR FUTURE-RESEARCH [J].
BACHMAN, DL ;
ALBERT, ML .
APHASIOLOGY, 1990, 4 (04) :407-413
[3]   PROGNOSTIC FACTORS IN APHASIA [J].
BASSO, A .
APHASIOLOGY, 1992, 6 (04) :337-348
[4]   INFLUENCE OF REHABILITATION ON LANGUAGE-SKILLS IN APHASIC PATIENTS - CONTROLLED-STUDY [J].
BASSO, A ;
CAPITANI, E ;
VIGNOLO, LA .
ARCHIVES OF NEUROLOGY, 1979, 36 (04) :190-196
[5]  
BICK RL, 1981, THROMB HAEMOSTASIS, V46, P67
[6]   EFFECTS OF PIRACETAM ON N-METHYL-D-ASPARTATE RECEPTOR PROPERTIES IN THE AGED MOUSE-BRAIN [J].
COHEN, SA ;
MULLER, WE .
PHARMACOLOGY, 1993, 47 (04) :217-222
[7]   TREATMENT OF ACQUIRED APHASIA - SPEECH THERAPISTS AND VOLUNTEERS COMPARED [J].
DAVID, R ;
ENDERBY, P ;
BAINTON, D .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1982, 45 (11) :957-961
[8]  
DEPRESSEUX JC, 1986, P INT S ORG SIR INT
[9]   TOKEN TEST - A SENSITIVE TEST TO DETECT RECEPTIVE DISTURBANCES IN APHASICS [J].
DERENZI, E ;
VIGNOLO, LA .
BRAIN, 1962, 85 (04) :665-678
[10]  
DIMOND S, 1979, NEUROPSYCHOLOGY LEAR, P367