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The multiple faces of glucagon-like peptide-1 - Obesity, appetite, and stress: What is next? A review

被引：23
作者：
Frezza, Eldo E.
Wachtel, Mitchell S.
Chiriva-Internati, Maurizio
机构：
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Surg, Div Gen Surg, Lubbock, TX 79145 USA
[2] Texas Tech Univ, Hlth Sci Ctr, Dept Pathol, Lubbock, TX 79145 USA
[3] Texas Tech Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, Lubbock, TX 79145 USA
来源：
DIGESTIVE DISEASES AND SCIENCES | 2007年 / 52卷 / 03期
关键词：
GLP-1; ghrelin; type; 2; diabetes; obesity; bariatric surgery; incretins; satiety; appetite; stress; oxyntomodulin;
D O I：
10.1007/s10620-006-9096-2
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
By itself, glucagon-like peptide-1(GLP-1) appears to be an excellent drug for appetite control and the treatment of obesity. Unfortunately, few enzymes, such as IV dipeptidyl peptidase and renal excretin, degrade and render GLP-1 inactive within minutes. A receptor agonist, exendin-4, with a longer biological half-life than GLP-1, has been tried. Subcutaneous injection of exendin-4 or continuous IV injection of GLP-1 warrants further research and investigation.
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收藏
页码：643 / 649
页数：7
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