Imaging [18F]FAU [1-(2′-deoxy-2′-fluoro-beta-D-arabinofuranosyl)uracil] in dogs

被引：14

作者：

Sun, HH

Collins, JM

Mangner, TJ

Muzik, O

Shields, AF ^{[1
]}

机构：

[1] Wayne State Univ, Karmanos Canc Inst, Dept Med, Detroit Med Ctr, Detroit, MI 48202 USA

[2] Wayne State Univ, Karmanos Canc Inst, Dept Radiol, Detroit Med Ctr, Detroit, MI USA

[3] US FDA, Bethesda, MD 20014 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2003年 / 30卷 / 01期

关键词：

FAU; PET; thymidine kinase;

D O I：

10.1016/S0969-8051(02)00376-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We have studied the biodistribution of [F-18]FAU [(1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil], which previous work has shown is incorporated into DNA and functions as an inhibitor of DNA synthesis. It is being tested as a potential antineoplastic agent and imaging agent for PET. We have produced [F-18]FAU and injected the tracer into 3 normal dogs and imaged them for up to 4 hours and removed tissues along with blood and urine samples for HPLC and activity analysis. The result, showed that [F-18]FAU evenly distributed to most of organs. In sharp contrast to our prior experience with thymidine and its analogs, marrow had less retention of [F-18]FAU than the non-proliferating tissues. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：25 / 30

页数：6

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