Anti-oligosaccharide antibodies as tools for studying sulfated sialoglycoconjugate ligands for siglecs and selectins

被引：13

作者：

Kannagi, Reiji ^{[1
]}

Ohmori, Katsuyuki ^{[2
]}

Kimura, Naoko ^{[1
]}

机构：

[1] Aichi Canc Ctr, Res Inst, Dept Mol Pathol, Nagoya, Aichi 4648681, Japan

[2] Kyoto Univ, Dept Clin Pathol, Sch Med, Kyoto 6068501, Japan

来源：

GLYCOCONJUGATE JOURNAL | 2009年 / 26卷 / 08期

基金：

日本科学技术振兴机构;

关键词：

Selectin; Siglec; CD22; Skin-homing helper memory T-lymphocytes; Cutaneous lymphocyte antigen; Naive B-lymphocytes; SIALYL-LEWIS-X; HIGH ENDOTHELIAL VENULES; HUMAN LYMPH-NODES; MONOCLONAL-ANTIBODY; MOLECULAR-CLONING; GLYCAN ARRAY; EXPRESSION; EPITOPE; IDENTIFICATION; LYMPHOCYTES;

D O I：

10.1007/s10719-008-9122-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several sulfated sialoglycoconjugates have recently been shown to serve as ligands for selectins and siglecs. For instance, alpha 2 -> 3 sialylated 6-sulfo-Lewis x was found to serve as a ligand for selectins on skin-homing helper memory T cells, and alpha 2 -> 6 sialylated 6-sulfo-LacNAc to be a preferred ligand for CD22/siglec-2 on human na < ve B cells. Monoclonal antibodies specific to sulfated sialoglycoconjugates are effective tools to dissect these ligands on minor subsets of human leukocytes.

引用

页码：923 / 928

页数：6

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