The salt-inducible kinase, SIK, is induced by depolarization in brain

被引：61

作者：

Feldman, JD

Vician, L

Crispino, M

Hoe, W

Baudry, M

Herschman, HR

机构：

[1] Univ Calif Los Angeles, Ctr Hlth Sci, Inst Mol Biol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Ctr Hlth Sci, Dept Pediat, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Ctr Hlth Sci, Dept Biol Chem, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Ctr Hlth Sci, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[5] Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA

[6] Univ Naples Federico II, Dept Gen & Environm Physiol, Naples, Italy

来源：

JOURNAL OF NEUROCHEMISTRY | 2000年 / 74卷 / 06期

关键词：

serine protein kinase; gene expression; depolarization; kainic acid; PC12; cells; representational difference analysis;

D O I：

10.1046/j.1471-4159.2000.0742227.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane depolarization of neurons is thought to lead to changes in gene expression that modulate neuronal plasticity, We used representational difference analysis to identify a group of cDNAs that are induced by membrane depolarization or by forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. One of these genes, SIK ((s) over bar alt-(i) over bar nducible (k) over bar inase), is a member of the sucrose-nonfermenting 1 protein kinase/AMP-activated protein kinase protein kinase family that was also recently identified from the adrenal gland of rats treated with high-salt diets. SIK mRNA is induced up to eightfold in specific regions of the hippocampus and cortex in rats, following systemic kainic acid administration and seizure induction.

引用

页码：2227 / 2238

页数：12

共 73 条

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