Water Dispersible Fe3O4 Nanoparticles Carrying Doxorubicin for Cancer Therapy

被引：17

作者：

Jayakumar, Onattu Damodharan ^{[1
]}

Ganguly, Rajib ^{[1
]}

Tyagi, Avesh Kumar ^{[1
]}

Chandrasekharan, Dhanya K. ^{[2
]}

Nair, Cherupally K. Krishnan ^{[2
]}

机构：

[1] Bhabha Atom Res Ctr, Div Chem, Mumbai 400085, Maharashtra, India

[2] Amala Canc Res Ctr, Trichur 680555, Kerala, India

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2009年 / 9卷 / 11期

关键词：

Fe3O4; Nanoparticles; TEM; Drug Delivery; Ferromagnetism; MAGNETIC NANOPARTICLES; DRUG-DELIVERY;

D O I：

10.1166/jnn.2009.1369

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water dispersible Fe3O4 nanoparticles (coated with Poly Vinyl Pyrolidone (PVP) and Poly oxy ethylene 25- propylene glycol stearate (POES)) and complexed with Doxorubicin has been prepared and characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The antitumor activity of these particles has been studied by targeting the complex to the tumor site, using an externally applied magnetic field, after oral administration of the magnetic nanoparticle-drug complexes. Our results reveal that the chemotherapy effect of Doxorubicin could be considerably enhanced by combination of the application of the drug-conjugated magnetic Fe3O4 nanoparticles, which are biocompatible and stable, and targeted drug delivery with a magnet. The present report provides the first evidence for the promising application of this novel approach with PVP coated Fe3O4 nanoparticles for cancer therapy using an in vivo murine model.

引用

页码：6344 / 6348

页数：5

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