A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families

被引：22

作者：

Zhao, Lan-Juan

Xiao, Peng

Liu, Yong-Jun

Xiong, Dong-Hai

Shen, Hui

Recker, Robert R.

Deng, Hong-Wen

机构：

[1] Univ Missouri, Sch Med, Dept Orthoped Surg, Kansas City, MO 64108 USA

[2] Univ Missouri, Sch Med, Dept Basic Med Sci, Kansas City, MO 64108 USA

[3] Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68131 USA

[4] Creighton Univ, Dept Biomed Sci, Omaha, NE 68131 USA

[5] Xian Jiaotong Univ, Sch Life Sci & Technol, Inst Mol Genet, Xian 710049, Peoples R China

[6] Xian Jiaotong Univ, Key Lab Biomed Informat Engn Minist Educ, Xian 710049, Peoples R China

[7] Hunan Normal Univ, Coll Life Sci, Lab Mol & Stat Genet, Changsha 410081, Hunan, Peoples R China

来源：

HUMAN GENETICS | 2007年 / 121卷 / 01期

关键词：

D O I：

10.1007/s00439-006-0286-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.

引用

页码：145 / 148

页数：4

共 11 条

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Multipoint quantitative-trait linkage analysis in general pedigrees [J].