Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist tADA

被引：11

作者：

Klein, J

Reymann, KG

Riedel, G

机构：

[1] FED INST NEUROBIOL,DEPT NEUROPHYSIOL,D-39008 MAGDEBURG,GERMANY

[2] UNIV YORK,DEPT PSYCHOL,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 02期

关键词：

metabotropic glutamate receptors (mGluRs); trans-azetidine-2,4-dicarboxylic acid (tADA); phospholipase C; phospholipase D; hippocampal slice;

D O I：

10.1016/S0028-3908(96)00174-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In hippocampal slices taken from 8-day-old rats, trans-azetidine-2,4-dicarboxylic acid (tADA), a novel glutamatergic agonist acting preferentially at class I mGluR receptors, activates phosphoinositide and phosphatidylcholine hydrolysis with widely different potencies. Inositol phosphate formation was maximally increased at 10 mu M tADA (EC(50): 1.2 mu M), while phospholipase D activation was observed at a tADA concentration of 1 mM. This is the first report of a tADA-induced phospholipase D activity. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：261 / 263

页数：3

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