Retroviral activation of the mir-106a microRNA cistron in T lymphoma

被引：58

作者：

Lum, Amy M.

Wang, Bruce B.

Li, Lauri

Channa, Namitha

Bartha, Gabor

Wabl, Matthias ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Picobella LLC, Burlingame, CA 94010 USA

[3] Synergen LLC, Burlingame, CA 94010 USA

来源：

RETROVIROLOGY | 2007年 / 4卷 / 1期

关键词：

D O I：

10.1186/1742-4690-4-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.

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