Cooperation of selection and meiotic mechanisms in the production of imbalances in reciprocal translocations

被引：47

作者：

Faraut, T ^{[1
]}

Mermet, MA ^{[1
]}

Demongeot, J ^{[1
]}

Cohen, O ^{[1
]}

机构：

[1] Univ Grenoble 1, Fac Med Grenoble, CNRS, Lab TIMC,IMAG,UMR 5525, F-38706 La Tronche, France

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 88卷 / 1-2期

关键词：

D O I：

10.1159/000015476

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have used data from chromosomally unbalanced offspring observed at birth, as well as data from sperm chromosome analysis, to study the meiotic segregation of reciprocal translocations. Using data from a total of 1,597 unbalanced children, we have observed an excess in maternal origin for all modes of imbalance. This excess is particularly marked for the 3:1 unbalanced mode, for which we have also observed a maternal age effect, indicating a close relationship with autosomal trisomies. In addition, a statistical analysis of data from 34 different published studies using sperm chromosome analysis has demonstrated that factors which, for reasons of viability, produce a predisposition for a particular mode of imbalance at birth also appear to favor meiotic production of this type of imbalance. Thus the production of unbalanced gametes of a particular type is influenced by the size of the imbalance. Copyright (C) 2000 S.Karger AG, Basel.

引用

页码：15 / 21

页数：7

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