Quantitative aspects of signal transduction by the receptor with high affinity for IgE

被引：12

作者：

Metzger, H ^{[1
]}

Eglite, S ^{[1
]}

Haleem-Smith, H ^{[1
]}

Reischl, I ^{[1
]}

Torigoe, C ^{[1
]}

机构：

[1] NIAMS, Sect Chem Immunol, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR IMMUNOLOGY | 2002年 / 38卷 / 16-18期

关键词：

aggregation; signal transduction; kinetic proofreading; gene activation; MCP-1;

D O I：

10.1016/S0161-5890(02)00065-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Identification of the major components, how these interact with each other, and the modifications that follow in the sequence of events triggered by the receptor with high affinity for IgE, is progressing rapidly. A new challenge is to understand these interactions quantitatively. We present the fundamentals of the mechanistic model we are testing through mathematical modeling. The object is to see if the predictions of the model fit with the experimental results. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1207 / 1211

页数：5

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