Na+ signals at central synapses

被引:35
作者
Rose, CR [1 ]
机构
[1] Univ Munich, Inst Physiol, D-80336 Munich, Germany
关键词
sodium; synapse; spine; dendrite; SBFI;
D O I
10.1177/1073858402238512
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A basic characteristic of animal cells is the maintenance of a steep inwardly directed electrochemical gradient for sodium ions. In vertebrate neurons, this Na+ gradient energizes intracellular ion regulation and enables influx of Na+ during action potentials and excitatory postsynaptic currents. Several studies suggested that Na+ ions could also play a role in activity-dependent synaptic plasticity. This review focuses on recent studies that demonstrated the presence of substantial intracellular Na+ transients during action potential firing or excitatory synaptic transmission in postsynaptic dendrites and dendritic spines. The large amplitudes of these activity-induced Na+ transients suggest that this signal will significantly alter electrical and biochemical properties of spines and dendrites and might influence the properties of synaptic transmission.
引用
收藏
页码:532 / 539
页数:8
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