Statins and the endothelium

被引：109

作者：

Ii, Masaaki

Losordo, Douglas W.

机构：

[1] Tufts Univ, Caritas St Elizabeths Med Ctr, Sch Med, Div Cardiovasc Res, Boston, MA 02135 USA

[2] RIKEN, Ctr Dev Biol, Stem Cell Translat Res, Chuo Ku, Kobe, Hyogo 6500047, Japan

[3] Inst Biomed Res & Innovat, Chuo Ku, Kobe, Hyogo 6500047, Japan

来源：

VASCULAR PHARMACOLOGY | 2007年 / 46卷 / 01期

关键词：

statin; endothelium; angiogenesis;

D O I：

10.1016/j.vph.2006.06.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Statins have been shown to have pleiotropic effects apart from serum lipid-lowering effect in human. One of the major target organs for the effects of statins is the vascular endothelium, which plays an important role in the development of atherosclerosis and angiogenesis. Recent numerous studies have shown that the statins' cholesterol-independent vascular effects appear to involve directly restoring or improving endothelial function by increasing NO production, promoting re-endothelialization after arterial injury, and inhibiting inflammatory responses within the vessel wall that are thought to contribute to atherosclerosis. This review provides an update of the unique effects of statins on endothelial cells including endothelial progenitor cells as well as highlighting the therapeutic potential of statins beyond their established lipid-lowering effects. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：1 / 9

页数：9

相关论文

共 107 条

[1] Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts [J].

Abbruzzese, TA ;

Havens, J ;

Belkin, M ;

Donaldson, MC ;

Whittemore, AD ;

Liao, JK ;

Conte, MS .

JOURNAL OF VASCULAR SURGERY, 2004, 39 (06) :1178-1185

[2] Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].

Aicher, A ;

Heeschen, C ;

Mildner-Rihm, C ;

Urbich, C ;

Ihling, C ;

Technau-Ihling, K ;

Zeiher, AM ;

Dimmeler, S .

NATURE MEDICINE, 2003, 9 (11) :1370-1376

[3] Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma [J].

Aikawa, M ;

Sugiyama, S ;

Hill, CC ;

Voglic, SJ ;

Rabkin, E ;

Fukumoto, Y ;

Schoen, FJ ;

Witztum, JL ;

Libby, P .

CIRCULATION, 2002, 106 (11) :1390-1396

[4] Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study [J].

Albert, MA ;

Danielson, E ;

Rifai, N ;

Ridker, PM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01) :64-70

[5] RETRACTED: Enhancement of ischemia-induced angiogenesis by eNOS overexpression (Retracted Article) [J].

Amano, K ;

Matsubara, H ;

Iba, O ;

Okigaki, M ;

Fujiyama, S ;

Imada, T ;

Kojima, H ;

Nozawa, Y ;

Kawashima, S ;

Yokoyama, M ;

Iwasaka, T .

HYPERTENSION, 2003, 41 (01) :156-162

[6] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[7] Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[8] 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (pravastatin) inhibits endothelial cell proliferation dependent on G1 cell cycle arrest [J].

Asakage, M ;

Tsuno, NH ;

Kitayama, J ;

Kawai, K ;

Okaji, Y ;

Yazawa, K ;

Kaisaki, S ;

Takahashi, K ;

Nagawa, H .

ANTI-CANCER DRUGS, 2004, 15 (06) :625-632

[9] HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes [J].

Assmus, B ;

Urbich, C ;

Aicher, A ;

Hofmann, WK ;

Haendeler, J ;

Rössig, L ;

Spyridopoulos, I ;

Zeiher, AM ;

Dimmeler, S .

CIRCULATION RESEARCH, 2003, 92 (09) :1049-1055

[10] THE ACUTE-PHASE RESPONSE [J].

BAUMANN, H ;

GAULDIE, J .

IMMUNOLOGY TODAY, 1994, 15 (02) :74-80

← 1 2 3 4 5 6 7 8 9 10 →