The development of strategies for construction of the aziridine core of the antitumor agents azinomycins A and B

被引：21

作者：

Coleman, RS ^{[1
]}

Carpenter, AJ ^{[1
]}

机构：

[1] UNIV S CAROLINA,DEPT CHEM & BIOCHEM,COLUMBIA,SC 29208

来源：

TETRAHEDRON | 1997年 / 53卷 / 48期

关键词：

D O I：

10.1016/S0040-4020(97)01017-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the C6-C13 aziridino[1,2a]pyrrolidine core substructure of the antitumor agents azinomycins A (1a) and B (1b) is described. Key synthetic steps included Wadsworth-Horner-Emmons olefination for formation of the C7-C8 double bond, an E-selective electrophilic bromination of the C8 position, and a stereospecific intramolecular addition-elimination reaction sequence for formation of the N-C8 pyrrolidine bond. (C) 1997 Elsevier Science Ltd.

引用

页码：16313 / 16326

页数：14

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