Only high concentrations of ethanol affect GABAA receptors of rat cerebellum granule cells in culture

被引：15

作者：

Casagrande, S.

Cupello, A.

Pellistri, F.

Robello, M.

机构：

[1] Univ Genoa, Dipartimento Fis, I-16146 Genoa, Italy

[2] CNR, Ist Bioimmagini & Fisiol, Genoa, Italy

来源：

NEUROSCIENCE LETTERS | 2007年 / 414卷 / 03期

关键词：

ethanol; GABA(A) receptors; granule cells;

D O I：

10.1016/j.neulet.2006.12.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the experiments described in the present report, we evaluated the effects of ethanol on the activity of GABA(A) receptors of cerebellar granule cells in culture. Only very high ethanol concentrations (100-300 mM) showed a clear and significant stimulatory effect on the activity of such receptors. This result was unexpected. In fact, previous reports from other groups would have suggested high ethanol sensitivity of at least one population of GABA(A) receptors expressed by granule cells. (c) 2007 Published by Elsevier Ireland Ltd.

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页码：273 / 276

页数：4

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