Otamixaban in acute coronary syndromes

被引:7
作者
Eikelboom, John W. [1 ,2 ]
Weitz, Jeffrey I. [2 ,3 ,4 ]
机构
[1] Hamilton Gen Hosp, Thrombosis Serv, Hamilton, ON L8L 2X2, Canada
[2] McMaster Univ, Dept Med, Hamilton, ON, Canada
[3] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada
[4] Henderson Res Ctr, Hamilton, ON, Canada
关键词
FACTOR XA INHIBITOR; FACTOR-IXA ACTIVITY; DOUBLE-BLIND; TRIAL; ASPIRIN;
D O I
10.1016/S0140-6736(09)61529-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:762 / 764
页数:3
相关论文
共 11 条
[1]   Apixaban, an Oral, Direct, Selective Factor Xa Inhibitor, in Combination With Antiplatelet Therapy After Acute Coronary Syndrome Results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) Trial [J].
Alexander, John H. ;
Becker, Richard C. ;
Bhatt, Deepak L. ;
Cools, Frank ;
Crea, Filippo ;
Dellborg, Mikael ;
Fox, Keith A. A. ;
Goodman, Shaun G. ;
Harrington, Robert A. ;
Huber, Kurt ;
Husted, Steen ;
Lewis, Basil S. ;
Lopez-Sendon, Jose ;
Mohan, Puneet ;
Montalescot, Gilles ;
Ruda, Mikhail ;
Ruzyllo, Witold ;
Verheugt, Freek ;
Wallentin, Lars ;
Darius, Harald ;
Simoons, Maarten ;
Boersma, Eric ;
DeLemos, James ;
Spencer, Fred .
CIRCULATION, 2009, 119 (22) :2877-U39
[2]   Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease [J].
Chan, Mark Y. ;
Cohen, Mauricio G. ;
Dyke, Christopher K. ;
Myles, Shelley K. ;
Aberle, Laura G. ;
Lin, Min ;
Walder, James ;
Steinhubl, Steven R. ;
Gilchrist, Ian C. ;
Kleiman, Neal S. ;
Vorchheimer, David A. ;
Chronos, Nicholas ;
Melloni, Chiara ;
Alexander, John H. ;
Harrington, Robert A. ;
Tonkens, Ross M. ;
Becker, Richard C. ;
Rusconi, Christopher P. .
CIRCULATION, 2008, 117 (22) :2865-2874
[3]   Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention - The SEPIA-PCI trial [J].
Cohen, Marc ;
Bhatt, Deepak L. ;
Alexander, John H. ;
Montalescot, Gilles ;
Bode, Christoph ;
Henry, Timothy ;
Tamby, Jean-Francois ;
Saaiman, Jan ;
Simek, Stanislas ;
De Swart, Johannes .
CIRCULATION, 2007, 115 (20) :2642-2651
[4]   First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology - A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity [J].
Dyke, Christopher K. ;
Steinhubl, Steven R. ;
Kleiman, Neal S. ;
Cannon, Richard O. ;
Aberle, Laura G. ;
Lin, Min ;
Myles, Shelley K. ;
Melloni, Chiara ;
Harrington, Robert A. ;
Alexander, John H. ;
Becker, Richard C. ;
Rusconi, Christopher P. .
CIRCULATION, 2006, 114 (23) :2490-2497
[5]   The discovery of the factor Xa inhibitor otamixaban: From lead identification to clinical development [J].
Guertin, Kevin R. ;
Choi, Yong-Mi .
CURRENT MEDICINAL CHEMISTRY, 2007, 14 (23) :2471-2481
[6]   Warfarin, aspirin, or both after myocardial infarction. [J].
Hurlen, M ;
Abdelnoor, M ;
Smith, P ;
Erikssen, J ;
Arnesen, H .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (13) :969-974
[7]   Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial [J].
Mega, J. L. ;
Braunwald, E. ;
Mohanavelu, S. ;
Burton, P. ;
Poulter, R. ;
Misselwitz, F. ;
Hricak, V. ;
Barnathan, E. S. ;
Bordes, P. ;
Witkowski, A. ;
Markov, V. ;
Oppenheimer, L. ;
Gibson, C. M. .
LANCET, 2009, 374 (9683) :29-38
[8]   RNA aptamers as reversible antagonists of coagulation factor IXa [J].
Rusconi, CP ;
Scardino, E ;
Layzer, J ;
Pitoc, GA ;
Ortel, TL ;
Monroe, D ;
Sullenger, BA .
NATURE, 2002, 419 (6902) :90-94
[9]   Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial [J].
Sabatine, Marc S. ;
Antman, Elliott M. ;
Widimsky, Petr ;
Ebrahim, Iftikhar O. ;
Kiss, Robert G. ;
Saaiman, Andre ;
Polasek, Rostislav ;
Contant, Charles F. ;
McCabe, Carolyn H. ;
Braunwald, Eugene .
LANCET, 2009, 374 (9692) :787-795
[10]   Aspirin and coumadin after acute coronary syndromes (the ASPECT-2 study): a randomised controlled trial [J].
van Es, RF ;
Jonker, JJC ;
Verheugt, FWA ;
Deckers, JW ;
Grobbee, DE .
LANCET, 2002, 360 (9327) :109-113