Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase

被引：40

作者：

Kim, DK ^{[1
]}

机构：

[1] Woosuk Univ, Coll Pharm, Samrye 565701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2002年 / 25卷 / 06期

关键词：

Corydalis incisa; Papaveraceae; acetylcholinesterase inhibitor; corynoline;

D O I：

10.1007/BF02976997

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 muM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.

引用

收藏

页码：817 / 819

页数：3

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