Measurement of glial fibrillary acidic protein in blood: an analytical method

被引：45

作者：

van Geel, WJA

de Reus, HPM

Nijzing, H

Verbeek, MM

Vos, PE

Lamers, KJB

机构：

[1] Univ Nijmegen, Ctr Med, Lab Pediat & Neurol, NL-6525 GC Nijmegen, Netherlands

[2] Byk Nederland BV, Zwanenburg, Netherlands

[3] Univ Nijmegen, Med Ctr, Dept Neurol, Nijmegen, Netherlands

来源：

CLINICA CHIMICA ACTA | 2002年 / 326卷 / 1-2期

关键词：

glial fibrillary acidic protein; severe traumatic brain injury; blood values;

D O I：

10.1016/S0009-8981(02)00330-3

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: In the present study, a new assay for the measurement of glial fibrillary acidic protein (GFAP) in human blood is described. The aim of the study was to present the characteristics of a new GFAP assay for blood analysis. Methods: The method, a newly developed enzyme-linked immunosorbent assay (ELISA), was validated using blood samples from healthy blood donors and from patients with severe traumatic brain injury (TBI). Results: 22 out of 72 healthy blood donors had a detectable GFAP level. The reference values (percentiles) are as follows: P50 = 0.15 mug/l and P95 = 0.49 mug/l; range 0.15-0.76 mug/l. Conclusions: GFAP in blood might be a promising new marker for astrocyte involvement after acute brain damage. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：151 / 154

页数：4

共 10 条

[1] Serum S-100 protein, relationship to clinical outcome in acute stroke [J].