Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development

被引：24

作者：

Gould, E ^{[1
]}

Tanapat, P ^{[1
]}

McEwan, BS ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEUROENDOCRINOL LAB,NEW YORK,NY 10021

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 101卷 / 1-2期

关键词：

adrenal steroid receptor; dentate gyrus; development; cell death; TUNEL; RU28362;

D O I：

10.1016/S0165-3806(97)00023-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration. (C) 1997 Elsevier Science B.V.

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收藏

页码：265 / 268

页数：4

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