Highly enantioselective water-compatible organocatalyst for Michael reaction of ketones to nitroolefins

被引：149

作者：

Vishnumaya ^{[1
]}

Singh, Vinod K. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1021/ol070082x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chiral diamine was found to catalyze enantioselective addition of ketones to nitroolefins in aqueous/saline/organic media. The products were obtained with excellent diastereoselectivities (synlanti = 99:1) and enantioselectivities up to 99%. The reaction could be facilitated using a mild acid.

引用

页码：1117 / 1119

页数：3

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