A Photocontrolled Molecular Switch Regulates Paralysis in a Living Organism

被引：137

作者：

Al-Atar, Usama ^{[1
]}

Fernandes, Rylan ^{[2
]}

Johnsen, Bob ^{[2
]}

Baillie, David ^{[2
]}

Branda, Neil R. ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Chem, LABS 4D, Burnaby, BC V5A 1S6, Canada

[2] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 44期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ja903070u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Using light to modulate biochemical agents in living organisms has a significant impact on photodynamic therapy and drug release. We demonstrate that a photoresponsive system can reversibly induce paralysis in nematodes as a model for living organisms when two different wavelengths of light are used to toggle the molecular switch between its two structural forms. This example illustrates how photoswitches offer great potential for advancing biomedical technologies. Copyright © 2009 American Chemical Society.

引用

页码：15966 / 15967

页数：2

共 15 条

[1]

Braeckman B.P., 2009, INTERMEDIARY METABOL, DOI [10.1895/wormbook.1.146.1, DOI 10.1895/WORMBOOK.1.146.1]

[2]

Goeldner M, 2005, DYNAMIC STUDIES IN BIOLOGY: PHOTOTRIGGERS, PHOTOSWITCHES AND CAGED BIOMOLECULES, P1, DOI 10.1002/3527605592

[3] Optical switches for remote and noninvasive control of cell signaling [J].

Gorostiza, Pau ;

Isacoff, Ehud Y. .

SCIENCE, 2008, 322 (5900) :395-399

[4]

Hobert Oliver, 2005, WormBook, P1

[5] Diarylethenes for memories and switches [J].

Irie, M .

CHEMICAL REVIEWS, 2000, 100 (05) :1685-1716

[6]

Irie M, 1999, T APPL CHEM, V1, P207

[7]

Irie M., 2001, MOL SWITCHES, P37, DOI DOI 10.1002/3527600329.CH2

[8]

Lemieux V., 2008, Angew. Chem. Int. Ed, V120, P5112

[9]

Livertoux MH, 1996, BRAIN RES, V725, P207, DOI 10.1016/S0006-8993(96)00251-X

[10] Modulating chemical reactivity using a photoresponsive molecular switch [J].

Samachetty, Hema D. ;

Lemieux, Vincent ;

Branda, Neil R. .

TETRAHEDRON, 2008, 64 (36) :8292-8300

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