Microbial transformation of (+)-adrenosterone

被引：21

作者：

Musharraf, SG ^{[1
]}

Atta-Ur-Rahman ^{[1
]}

Choudhary, MI ^{[1
]}

Sultan, S ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

来源：

NATURAL PRODUCT LETTERS | 2002年 / 16卷 / 05期

关键词：

fungal transformation; adrenosterone; Cephalosporium aphidicola; Fusarium lini; Trichothecium roseum;

D O I：

10.1080/10575630290033105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microbial transformation of (+)-adrenosterone (1) by Cephalosporium aphidicola afforded three metabolites identified as androsta-1,4-diene-3,11,17-trione (2), 17beta-hydroxyandrost-4-ene-3,11-dione (3) and 17beta-hydroxyandrosta-1,4-diene-3,11-dione (4). The fermentation of 1 with Fusarium lini also produced metabolites 2 and 4, while the fermentation with Trichothecium roseum afforded metabolite 3. The structures of transformed products were determined by spectroscopic methods.

引用

页码：345 / 349

页数：5

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