Level of transforming growth factor beta 1 is elevated in cerebrospinal fluid of children with acute bacterial meningitis

被引:12
作者
Huang, CC
Chang, YC
Chow, NH
Wang, ST
机构
[1] KAOHSIUNG CHANG GUNG CHILDRENS HOSP,DEPT PEDIAT,KAOHSIUNG,TAIWAN
[2] NATL CHENG KUNG UNIV,DEPT PATHOL,TAINAN 70101,TAIWAN
[3] NATL CHENG KUNG UNIV,DEPT PUBL HLTH,MED CTR,TAINAN 70101,TAIWAN
关键词
bacterial meningitis; cerebrospinal fluid; transforming growth factor beta 1;
D O I
10.1007/s004150050159
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We investigated the levels of transforming growth factor beta 1 (TGF-beta 1)in cerebrospinal fluid (CSF) in children with meningitis, with a view to prognostic relevance. CSF TGF-beta 1 levels on admission were measured by a sandwich enzyme immunoassay in children with bacterial meningitis (n = 16), aseptic meningitis (n = 12), and control subjects without evidence of central nervous system (CNS) Infection (n = 16). Patients were followed up for a mean duration of 13 months, and neurodevelopmental sequelae was determined for those with bacterial meningitis, On admission, CSF TGF-beta 1 levels were significantly higher in children with bacterial meningitis (mean, standard error, 32.92, 2.36 pg/ml) as opposed to those with aseptic meningitis (25.26, 1.72 pg/ml) (P = 0.0155), or control subjects (20.53, 1.05 pg/ml) (P < 0.0001). The CSF TGF-beta 1 levels in children with aseptic meningitis were higher than those in the control group, but without significance (P = 0.02). No apparent correlation existed between CSF TGF-beta 1 levels and CSF protein or cell counts in patients with bacterial meningitis, No significant difference in CSF TGF-beta 1 levels was found between patients with or without major sequelae following bacterial meningitis.
引用
收藏
页码:634 / 638
页数:5
相关论文
共 25 条
  • [1] CEREBROSPINAL-FLUID CACHECTIN TUMOR NECROSIS FACTOR-ALPHA AND PLATELET-ACTIVATING FACTOR CONCENTRATIONS AND SEVERITY OF BACTERIAL-MENINGITIS IN CHILDREN
    ARDITI, M
    MANOGUE, KR
    CAPLAN, M
    YOGEV, R
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (01) : 139 - 147
  • [2] SURVEILLANCE, INTERVENTION AND CYTOTOXICITY - IS THERE A PROTECTIVE ROLE OF MICROGLIA
    BANATI, RB
    GRAEBER, MB
    [J]. DEVELOPMENTAL NEUROSCIENCE, 1994, 16 (3-4) : 114 - 127
  • [3] CYTOKINE ELEVATIONS IN INFANTS WITH BACTERIAL AND ASEPTIC-MENINGITIS
    DULKERIAN, SJ
    KILPATRICK, L
    COSTARINO, AT
    MCCAWLEY, L
    FEIN, J
    CORCORAN, L
    ZIRIN, S
    HARRIS, MC
    [J]. JOURNAL OF PEDIATRICS, 1995, 126 (06) : 872 - 876
  • [4] INHIBITION OF CYTOKINE PRODUCTION BY CYCLOSPORINE-A AND TRANSFORMING GROWTH-FACTOR-BETA
    ESPEVIK, T
    FIGARI, IS
    SHALABY, MR
    LACKIDES, GA
    LEWIS, GD
    SHEPARD, HM
    PALLADINO, MA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (02) : 571 - 576
  • [5] MODULATION OF THE IMMUNE-RESPONSE BY TRANSFORMING GROWTH-FACTOR-BETA
    FONTANA, A
    CONSTAM, DB
    FREI, K
    MALIPIERO, U
    PFISTER, HW
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1992, 99 (01) : 1 - 7
  • [6] GAMBLE JR, 1988, SCIENCE, V242, P97
  • [7] AMINO-ACIDS IN CEREBROSPINAL AND BRAIN INTERSTITIAL FLUID IN EXPERIMENTAL PNEUMOCOCCAL MENINGITIS
    GUERRAROMERO, L
    TUREEN, JH
    FOURNIER, MA
    MAKRIDES, V
    TAUBER, MG
    [J]. PEDIATRIC RESEARCH, 1993, 33 (05) : 510 - 513
  • [8] HERSON VC, 1977, PEDIATRICS, V59, P35
  • [9] JOHNSON MD, 1992, LAB INVEST, V67, P360
  • [10] KORSCHING S, 1993, J NEUROSCI, V13, P2739