The Prevalence of Transmitted Antiretroviral Drug Resistance in Treatment-Naive HIV-Infected Individuals in China

被引:79
作者
Liao, Lingjie [1 ]
Xing, Hui [1 ]
Shang, Hong [2 ]
Li, Jingyun [3 ]
Zhong, Ping [4 ]
Kang, Laiyi [4 ]
Cheng, Hua [1 ,4 ]
Si, Xuefeng [1 ]
Jiang, Shulin [1 ]
Li, Xinping [1 ]
Shao, Yiming [1 ]
机构
[1] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 100050, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Minist Hlth, Key Lab Immunol AIDS, Shenyang, Liaoning Prov, Peoples R China
[3] Acad Mil Med Sci, Inst Microbiol & Epidemiol, AIDS Res Dept, Beijing, Peoples R China
[4] Shanghai Municipal Ctr Dis Control & Prevent, Dept AIDS & STD, Shanghai, Peoples R China
基金
美国国家卫生研究院;
关键词
prevalence; treatment naive; transmitted HIV-1 drug resistance; MUTATIONS; DIVERSITY; HIV/AIDS; PROGRAM;
D O I
10.1097/QAI.0b013e3181c7d363
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Background: Transmission of HIV drug resistance (TDR) gives rise to reduced efficacy of initial antiretroviral treatment and has become a public health concern. Methods: A nationwide survey on TDR was conducted in antiretroviral therapy-naive HIV-1-infected individuals from September 2004 to October 2005 in China. Drug resistance genotyping was performed on subjects' plasma samples. Drug resistance mutations were determined and. scored by Stanford HIV Drug Resistance algorithm. Results: Sequences were obtained from 676 individuals, of whom 61.2% were former plasma and blood donors, 17.3% were infected sexually, and 17.2% were intravenous drug users. Subtype B' HIV-1 strains were found in 73.5%, CRF01_AE in 13.9%, CRF07_BC in 6.2%, CRF08_BC in 2.7%, subtype C in 1.04%, subtype B in 0.9%, CRF02_AG in 0.4%, and B'/C intersubtype recombinant strains in 1.3% of the subjects. Twenty-six (3.8%) were found to harbor drug resistance strains. The rates of resistance to protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors were 0.4%, 1.6%, and 2.1%, respectively. Though there was no significant difference in TDR rates between 2004 and 2005 (2.9% vs. 4.4%), an increased trend was observed in the rate of high-level drug resistance (0.8% in 2004 vs. 3.0% in 2005, P = 0.0634). Conclusions: The rate of TDR was relatively low in China, as compared with those in developed countries. Surveys among recently HIV-infected subjects should be performed continually to ensure the success of the scale-up antiretroviral treatment.
引用
收藏
页码:S10 / S14
页数:5
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